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Increases in sympathetic outflow remain the largest safety concern for melanocortin agonists after compounds such as LY2112688 and bremelanotide demonstrated increases in both blood pressure and heart rate in clinical trials (150)

GLP-1 analogues may be referred to as GLP-1 agonists or GLP-1 mimetics

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A clinical intake with labs helps confirm which system is most depleted

12 Oxidative stress, 13 mitochondrial dysfunction, 14 and endoplasmic reticulum (ER) stress 15 are all involved in NDs induced by brain IR