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Alternatively, the direct link between creatine and the pulmonary dimension might be explained by the attenuation of prolonged inflammation and lung ischemic injury after acute disease [10], in parallel with what has been observed as a consequence of lung transplantation [75]

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First, the majority of available data are derived from in vitro and animal models, which do not fully capture the complexity, heterogeneity, and long-term progression of human neurodegenerative diseases