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Indeed, we find that excessive iron can induce multiorgan dysfunction in mice, which is dominantly driven by ferroptosis through excessive lipid peroxidation-induced injury

This highlights the potential treatment role of targeting the NLRP3 pathway in managing cardiac complications associated with dysbiosis and LPS-induced inflammation

Increasing evidence indicates that PSC activation plays an important role in the progression of islet fibrosis in T2DM patients and animal models [7, 33, 34]

Medications can also influence B12 metabolism

Psychiatric safety of semaglutide for weight management in people without known major psychopathology: post hoc analysis of the STEP 1, 2, 3, and 5 Trials