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Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]
Its astonishing skin lightening ability is harnessed to treat melasma and whiten skin
Oxidative stress is the disturbance in the balance between the generation of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), and antioxidant defenses, and can cause oxidative damage to diverse cellular components, such as membranes, proteins, and DNA
[DOI] [PMC free article] [PubMed] [Google Scholar] 203.Krezel A., Maret W
It also assists in protein synthesis, DNA repair, enzyme function, transport, and cell maturation
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