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4 TLS can occur following the administration of chemotherapy or spontaneously in cancer types with high proliferative rates or large tumor burden

Santos-Daz AI, Bizup B, Pantalen-Gmez AK, Osorio B, Barbier OC, Tzounopoulos T, et al

First, H 2 O 2 /O/OH can regulate the expression of genes related to nucleotide metabolism by transcriptionally regulating signaling pathways such as NRF2 and p53, thereby affecting the synthesis and degradation of nucleotides [206]

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Injection site reactions including temporary redness, swelling, or itching occur occasionally