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Treatment begins at a low starting dose and is titrated upward over several weeks or months under medical supervision until a therapeutic maintenance dose is reached

The risk of spread (metastatic melanoma) from invasive melanoma depends on several factors, but the main one is the thickness of the melanoma at the time it was surgically removed

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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Heerspink HJL, Apperloo E, Davies M, Dicker D, Kandler K, Rosenstock J, Srrig R, Lawson J, Zeuthen N, Cherney D