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Although the number of published studies is still limited, the integration of patient derived primary cells and organoids into OoC systems is emerging as a powerful approach to advance personalized therapy design and mechanistic disease investigation (145)

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

CVOTs have become a cornerstone in evaluating antidiabetic medications, mandated by regulatory agencies to ensure that these drugs do not exacerbate cardiovascular risk

The plan is to offer patients a long-term extension period for their trials, giving whoever receives the placebo a chance to then switch and take the experimental drug