Taken together, evidence of early locus coeruleus pathology in AD and PD, reductions in norepinephrine transporters with aging, AD and PD, and robust norepinephrine transporter engagement by antidepressants point to the norepinephrine transporter as a critical, yet understudied target in LLD [169, 178]
Che DN, Cho BO, Kim JS, Shin JY, Kang HJ, Jang SI (2020) Effect of luteolin and apigenin on the production of Il-31 and Il-33 in lipopolysaccharides-activated microglia cells and their mechanism of action
Oxidized GSSG (Functionally Inactive) GSSG is the oxidized form of glutathione, which loses its antioxidant properties and therefore does not directly protect cells
More information here
Glutathione is generally considered safe for most individuals