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Some patients report increased abdominal discomfort, cramping, or bloating when initiating therapy, which may be particularly distressing for individuals already experiencing heightened gut sensitivity

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Advise patients on the symptoms of hypersensitivity reactions and instruct them to stop taking RYBELSUS or OZEMPIC tablets and seek medical advice promptly if such symptoms occur [see Warnings and Precautions (5.7)]

Gastrointestinal side effects, including nausea, vomiting, and diarrhea, are extremely common with GLP-1 therapy and may exacerbate nutritional deficits while directly contributing to feelings of unwellness and fatigue

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