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The article suggested that the concentration of endogenous N/OFQ, although elevated in asthma, is too low to modulate the immune system and AHR [43]

If the injection is given IV (slowly), there may be a brief sensation of warmth or a mild flushing during the infusion, owing to the niacinamide component

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In other embodiments, the delivery system comprises multiple syringes, each syringe of the multiple syringes contains at least one component of the formulation such that each component is pre-mixed prior to injection or is mixed subsequent to injection