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NAD+ is generally considered safe and does not have significant interactions with most common medications

doi:10.1016/j.eclinm.2024.102475 Manne-Goehler J, Teufel F, Venter WDF

Step 4: For first-time use only, prime the pen

Most patients experience peak nausea during weeks one through three, with noticeable improvement by week four and near-complete resolution by weeks six to eight