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Severe renal impairment-especially anuria (inability to produce urine)-is a primary contraindication

10.1016/j.domaniend.2023.106805 55 FbreguesF.FerreriJ.MndezM.CalafellJ

Thyroid Treatment : For those with thyroid imbalances, addressing thyroid health may be key in improving energy levels

Reports of GLP-1 RA regulation of thirst in animals is of interest, but the clinical relevance is not yet obvious

Despite encouraging preclinical efficacy, no clinical trials have yet been initiated in liver fibrosis, highlighting the gap between mechanistic promise and translational feasibility (179)