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Beyond fat loss, Tesamorelin increases lean body mass by 1.42 kg across randomized clinical trials, improves lipid profiles (reducing triglycerides by 48 mg/dL and total cholesterol by 8 mg/dL at 52 weeks), and lowers hepatic fat fraction by 4.9% at 12 months in patients with NAFLD

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Furthermore, the high metabolic activity of perirenal fat may affect bone metabolism through other mechanisms

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