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GLP-1 (Glucagon-like Peptide-1) is a hormone that sends signals to the brain to feel full and slows down the speed at which food leaves your stomach

In the SUMMIT trial, Packer et al

As GLP-1 levels increase, the body registers that it has had enough to eat and reduces hunger cravings as a result

Overweight and Obese Adults, 2018: Statistics Canada

There are no trials of the amlodipine/valsartan/hydrochlorothiazide combination tablet demonstrating reductions in cardiovascular risk in patients with hypertension, but both the amlodipine and hydrochlorothiazide components and several ARBs, which are the same pharmacological class as the valsartan component, have demonstrated such benefits