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This cascade of metabolic dysregulation not only directly induces the phenotype switching of PASMCs from a contractile to a highly proliferative and migratory synthetic phenotype [132] but also causes significant medial wall thickening, ultimately driving PH disease progression

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192 Similarly, inhibiting Nrf2/Keap1/SLC7A11 pathway to promote ferroptosis in gastric cancer cells also increases the sensitivity of gastric cancer to cisplatin

thus a deficiency may lead to disruption of DNA synthesis/cell metabolism and have serious clinical consequences

Taking the vial out of the fridge, letting it warm up, and then putting it back repeatedly is not ideal