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Trimetazidine is lipophilic and crosses the blood-brain-barrier [112], hence it is highly likely to exert anti-inflammatory effects also in the brain

As we age, our stomachs produce less hydrochloric acid or stomach acid, which is needed to absorb B12

However, it is not readily absorbed because the body needs to go through several conversion steps before it becomes usable

However, the oral route cannot be excluded as it did not depend on intrinsic factors only, as the simple diffusion (without the need for intrinsic factors) is now considered another mechanism for the absorption of vitamin B12 [49, 50]

Beyond 6 weeks: Preservative largely ineffective