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Thus, the dissociation of Cu(II) ions from HSA in the presence of EDTA is relatively slow and the affinity of Cu(II) for HSA is lower than that for EDTA

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Furthermore, side effects of the two medications vary

Tissue hypoxia and oxidative stress also can contribute to non-immune mediated tissue injury driven by renal stromal cells, further enhancing interstitial immune cell infiltration and fibrosis to create a viscous cycle3