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Description

For context on timelines with similar compounds, see our guide on semaglutide appetite suppression timelines

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This prohibition remains in effect

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Int J Mol Sci 2020, 21(4)

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However, native GLP-1 has a limited half-life (1.55 min) due to its degradation by the enzyme Dipeptidyl peptidase 4 (DPP-4), necessitating the development of GLP-1 receptor agonists (GLP-1RAs) with longer activity (Campbell and Drucker 2013)

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According to this characteristic, GLP-1RA gradually entered the clinic

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