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Letters asking for the changes have been sent to GSK, which makes Flulaval and Fluarix, AstraZeneca (FluMist), Sanofi (Fluzone), and Seqirus (Afluria and Flucelvax) from Center for Biologics Evaluation and Research (CBER) director Vinay Prasad

As indicated above, migraine is a brain disorder related to disturbances in the brain homeostasis and leading to, among others, activation of the trigeminovascular system, stimulation of cerebral vessels nociceptors, and further signal transmission in the brain

All of the participants provided written informed consent