however, if SGLT2is are not tolerated or are contraindicated, or if eGFR is less than adequate, a GLP-1RA with proven CV benefit can be added ( In recent guidelines on diabetes, prediabetes, and CVD from the European Society of Cardiology, in collaboration with the EASD, GLP-1RAs with proven CV benefit (liraglutide, semaglutide, and dulaglutide) are recommended as an add-on therapy to metformin ( Mechanisms for the Cardiovascular Benefits of GLP-1RAS Different mechanisms have been proposed to explain the CV benefits elicited by some GLP-1RAs ( 1c , body weight, and systolic blood pressure were also those associated with CV-event reduction
Celiker, R., Borman, P., Oktem, F., Gokce-Kutsal, Y
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A1C=glycated hemoglobin
At the same time, a large 2026 analysis introduced warning signs the orthopedic community cannot ignore