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GLP-1 RAs are generally prescribed at higher doses for weight loss rather than for control of T2D, do GLP1-RA therapy in patients with T2D have the same incidence of gallbladder or biliary diseases compared with GLP1-RA in patients treated for obesity

Patients experiencing GLP-1 digestion issues may notice bloating, infrequent bowel movements, or abdominal discomfort-especially during the first few weeks or when doses increase

Many people experience improved water balance after 4-6 weeks on semaglutide, as their metabolism stabilizes and inflammation related to excess weight decreases

Randomized, double-blind, placebo-controlled trial of orlistat for weight loss in adolescents

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