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It should be noted that in vitro IC 50 concentrations may not directly reflect clinically achievable plasma or tissue levels, and translational interpretation requires pharmacokinetic validation

For example, in TLR7 agonist-induced lupus mouse model, delayed treatment with 6-gingerol from week 4 and for 2 weeks greatly reduced plasma NET levels, autoantibody formation (e.g., anti-dsDNA and anti-2GPI antibodies), and thrombosis but not total leukocytes or spleen size (162)

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10.1016/j.yjmcc.2013.12.015 J Mol Cell Cardiol

Amyloid -Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143-Further Implications for Alzheimers Therapy