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Collectively, these findings provide a mechanistic rationale for developing multi-target agonists: GLP-1R appears to provide the most potent and direct anti-MASLD and anti-fibrotic effects in the liver, while GIPR and GCGR offer complementary benefits for glucose and lipid metabolism, with GIPR also exhibiting superior cardiovascular protection

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In a post-hoc analysis of a phase 2b trial enrolling 316 patients with T2D, Thomas et al

If you're approved, start the program, and then decide it's not for you after medication has been shipped - the refund policy limits your options

Harris, E