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With age, the amount of elastic tissue in the phrenoesophageal membrane progressively declines, increasing its laxity and increasing the risk for developing hiatal hernias [6, 7]

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A.LiQ.IshikadoA.KanntA.SadowskiT.et al (2017)

Graphical Abstract 1 Introduction Reactive oxygen species (ROS) are a group of highly reactive, short-lived oxygen-containing molecules that are present in both biological systems and the environment ( As the largest organ of the human body and the first line of defense against the external environment, the skin can shield the internal organs from damage ( 2 Sources of ROS in the skin and initiation of oxidative stress There are two main sources of ROS in the skin: endogenous and exogenous