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For the co-primary endpoints, retatrutide reduced weight by up to an average of 28.7% (71.2 lbs) and reduced pain by up to an average of 4.5 points (75.8%) using the WOMAC pain score

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Decreasing the level of acetylcarnitine can reduce the acetylation of -catenin and promote its nuclear accumulation, leading to excessive activation of the Wnt/-catenin signaling pathway [39]

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