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The Journal of Clinical Endocrinology and Metabolism, 106, 388396

Investigating two different cohorts (combined n = 3163), it was validated that individuals with high 2PY or 4PY levels have an increased risk of major adverse cardiovascular events

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Furthermore, both randomized control trials (RCTs) and real-world observational studies have reported improvements in all-cause mortality and CV mortality with both drug classes (21, 22) compared with other glucose-lowering therapies, even though the mechanisms involved have yet to be completely elucidated (2325)