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MOTS-c increases cellular NAD+ levels as part of its mechanism, so the two compounds work through complementary pathways rather than redundant ones

Clinical studies and meta-analyses suggest that ALA supplementation can lead to small but meaningful improvements in fasting glucose and insulin sensitivity, particularly in people with type 2 diabetes or metabolic syndrome.2 24 That said, these effects are generally modest and ALA should never be viewed as a substitute for prescribed diabetes medications

4 Physiotherapy Programme, School of Rehabilitation Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems

This phase often brings improvements in energy levels, mood, and motivation

The New England Journal of Medicine, 375, 311322