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We approached this by identifying omics- features (i.e., expression, mutation, copy number, pathways, metabolites, etc.) that are predictive of NRF2 CRISPR knockout scores from the DepMap

PMID: 34267654 | doi:10.3389/fphar.2021.627533 Sikiric P et al

Female or male age-matched mice (712 weeks old) were used for all experiments (unless otherwise stated) and euthanasia was performed by cervical dislocation

YabeDKuroeALeeSWatanabeKHyoTHishizawaMet al

After 4 weeks of oral pycnogenol treatment an inhibition of NF-Bdependent gene expression found to be lowered which further blocked inflammatory signaling [83]