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As LAC can regulate metabolic factors and reduce glutamate spillover, it can quickly improve depression and also be considered for the treatment of insulin resistance in patients with depression (85)

doi: 10.1186/1471-2288-14-43

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Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype