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Vahjen et al., 2010

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Conditional Cre-induced inactivation of the Glp1r gene was carried out via 5 consecutive daily gavages of 100 L of 10 mg/mL tamoxifen (Sigma-Aldrich T5648) diluted in corn oil (1 mg/mouse) after mice reached 8 weeks of age

in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac (Okada et al., 2011

By proteomic analysis the muscle tissue revealed a profound loss of Complex I subunits from the respiratory chain and to some extent also deficiency of Complex II and IV