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Immunobiology 222 , 423431 (2017)

Patients with type 1 diabetes require insulin therapy and should not use tirzepatide as a replacement for insulin

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More importantly, the hazard ratio for major adverse cardiovascular events (including cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina) for the pooled tirzepatide groups versus glargine was 0.74 (95% CI 0.511.08), suggesting no increased cardiovascular risk with tirzepatide compared to insulin glargine