Leone S, Chiavaroli A, Shohreh R, Ferrante C, Ricciuti A, Manippa F, et al
45 In showing significant associations between latitude as a surrogate measure of UVR and the frequency of four gene polymorphisms that influence folate cofactor partitioning in folate metabolism, the present findings may provide new insight into folate-related diseases
There is significant research citing a connection between a deficiency in the MTHFR enzyme caused by a mutation in the MTHFR gene and increased prevalence and risk for psychiatric disorders such as schizophrenia and major depressive disorder
What it does is reduce local inflammation, support the maintenance of remaining tissue, and in some cases improve synovial health in a way that changes the pain experience meaningfully
doi: 10.1152/physrev.00062.2017, 25 DionisioP