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Researchers should establish baseline data for each compound individually before assessing combinatorial effects, and all protocols should follow applicable institutional research guidelines

This medicine is also less likely to cause unwanted effects when there is a constant amount in the blood

Other serious but rare side effects include pancreatitis (severe stomach pain, fever, nausea, vomiting), gallbladder problems (yellowing of skin or eyes, upper stomach pain), kidney injury (decreased urination, swelling), diabetic retinopathy (vision changes), severe allergic reactions (rash, swelling of face/throat, difficulty breathing), increased heart rate, and new or worsening depression or suicidal thoughts

But anyone who experiences it regularly knows it can feel far more uncomfortable than just being full