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Exhibit 10 As of February 2017, 39 FIDE SNPs were operating in eight states (Arizona, California, Idaho, Massachusetts, Minnesota, New Jersey, New York, and Wisconsin), with a total enrollment of 136,677 dual eligible beneficiaries (CMS, 2017a)

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Zebrafish-based small molecule discovery

Our previous work using a zebrafish model system revealed that GCGR deficiency not only induces -cell hyperplasia but also upregulates glucagon gene ( Gcg ) expression in cells 16