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Furthermore, Macaulay et al also observed significant increases in the fMRI-derived fraction of low frequency fluctuations in the cerebellum, right middle temporal gyrus, and bilateral inferior parietal lobes, representing greater functional neuronal integrity and connectivity between brain regions (Macaulay et al., 2022)

Indicatively, the demonstrated leading role of rapid heart disturbances and general vascular failure in the major vessels-induced occlusive syndromes [14,15,16,17,18,19,20] and in occlusion-like syndrome with major intoxication (alcohol, lithium) or maintained severe intra-abdominal hypertension [21,22,23] means in the isoprenaline-treated rats, isoprenaline was detected as an early syndrome of multiorgan failure, peripherally and centrally

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