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Similarly, exenatide-4 inhibits hepatocarcinogenesis independent of obesity and MASH resolution, acting through the cAMP-PKA-EGFR-STAT3 axis and mTOR modulation to suppress proliferation and reduce HCC multiplicity (Zhou et al., 2017)

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Obesity is epidemic in the United States, where some 40% of adults and 21% of children and teens are obese, according to the Trust for a Better Health's State of Obesity Report 2025