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Pouliot, J

A negative trial result may indicate lack of drug access to the brain, rather than failure of the concept itself, Paul Edison, a professor of neuroscience at Imperial College London, explained

Many trials used twicedaily dosing

This is a convention that recurs across such protocols, not a specification derived from a controlled trial: no controlled human study has examined or validated this specific ratio

Runners who experience persistent GI symptoms should slow dose escalation (stay at a lower dose for 68 weeks instead of 4 weeks) or consider switching to a different GLP-1 medication with better individual tolerance