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This benefit corresponded to 51 fewer active cases of kidney stones per 1,000 person years overall, and 219 fewer cases per 1,000 person years among those with recently active kidney stones

It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question