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Studies in laboratory animals confirm the etiological role of cytokines in liver damage in ALD, with elevated levels of tumor necrosis factor alpha (TNF-) and TNF--induced cytokines/chemokines such as interleukins (IL) -6, 8 or 18, and that the levels of these cytokines correlate with markers of the acute phase response, liver function and the clinical picture of the disease (66)

It contains high levels of the sulfur-containing amino acid cysteine

4j), highlighting a further distinction between ferroptosis induced by ESA and canonical ferroptosis inducers