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400 Researchers have discovered that GLP-1RAs exhibit a noticeable increase in the level of phosphorylated ERK1/2 within the sciatic nerve of diabetic rats

Newsome PN, Ambery P

Dose-related GI symptoms during the rapid titration phase are a well-documented cause of patients quitting GLP-1 therapy (source)

Accessibility: GLP-1 therapy : High costs (up to $1,000-$1,500 monthly without insurance) can be a barrier, though insurance coverage may reduce out-of-pocket expenses for eligible patients

GLP-RTsupplied by New England Biologics must only be handled by trained laboratory personnel familiar with safe chemical handling practices and research material protocols