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Researchers have yet to isolate the DSIP gene or identify its receptor, leading some to question whether the peptide exists naturally or only under artificial conditions

( B ) Under conditions of APAP overdose along with iron overload, the excessive cellular free iron reacts with mitochondrial reactive oxygen species (ROS) to induce lipid peroxidation (LPO) of membranes

The distinction matters enormously

Garstkiewicz M, Strittmatter GE, Grossi S, Sand J, Fenini G, Werner S et al (2017) Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression

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