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Zhen Tian, [email protected] These authors have contributed equally to this work This article was submitted to Pediatric Oncology, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Drucker DJ, Habener JF, Holst JJ

The fluorescence was detected by fluorescence microscope (Nikon, Ts2R) and flow cytometry (BD, FACSCelesta)

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Splitting a larger daily dose into two smaller administrations (e.g., 500mcg in the morning and 500mcg in the evening instead of 1mg at once) is a strategy to maintain more stable blood levels of the peptide and potentially reduce the intensity of side effects