Selenium is a cofactor for enzymes that are present in thyroid cells, such as iodothyronine deiodinase (DIO), which catalyzes the conversion of T4 to T3, thioredoxin reductase (TR), which is involved in the regulation of the redox state, and glutathione peroxidase (GPx), which catalyzes the reduction of H 2 O 2 to H 2 O, using reduced glutathione (GSH) as a cosubstrate
As a conclusion, accurate recognition of the imaging features of MNTI combined with history and clinical manifestations (early infancy, painless, firm, pigmented mucosa, non-ulcerating lesion) can provide clues for diagnosis of this rare entity
Early-phase clinical trials including a Phase 2 dose-ranging study published in the New England Journal of Medicine (2023) have demonstrated significant potential for weight reduction and metabolic improvement, generating considerable scientific interest
Skin whitening treatments are readily available on the market in various forms
Whereas the present results show that 6/32 cases were GLP1R positive, representing 18% of all our PanIN cases, it should be stressed that the 6 positive cases were all of the PanIN 1/2 type, and that the 12 cases with PanIN 3 were all negative
