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As a replacement strategy, lithium orotate (LiO), reported to bind A less avidly than lithium carbonate, raised parenchymal Li, reduced A and phospho-tau, and improved synaptic/myelin markers and behavior at physiological Li levels in AD mice, though these salt-specific advantages and translational implications remain preclinical [2123]

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3, moderate redness and swelling from ankle to metatarsal joints

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Yet, the long-term effects of these changes are unknown ( Therefore, more information is needed concerning long-term supplementation, particularly when high doses are used