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A protocol planned interim analysis was conducted for this cross-over study when 12 participants completed the first administration period (period 1), in order to re-assess the sample size based on the primary outcome data

The clinical failure of NLY01 in PD, despite evidence of CNS penetration in nonhuman primates (158), underscores the uncertainty around how brain access relates to clinical efficacy

Notably, metabolic reprogramming has been implicated in the pathological features of fibroblast/myofibroblast activation

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