Polypharmacy also includes situations where medications are used for inappropriate reasons, unnecessarily combined, or prescribed to treat the adverse effects of other drugs
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258 Additionally, TREM2 has emerged as a potential therapeutic target due to its potential role in early AD in modulating neuroinflammation, A plaque deposition, and cognitive abilities
Notably, studies highlight the insulin-potentiating action associated with the N-terminal region, while amino acids 108-129 elicit high mitogenic responses