Denaturation The natural or native structures of proteins may be altered, and their biological activity changed or destroyed by treatment that does not disrupt the primary structure
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Given the observed rates of excretion in urine and feces, about 2025% is expected to be present in the organism at 168 h after administration, and about 3035% of the dose has probably been eliminated given 3 H20 in expired air after metabolization of the test compound and isotope exchange with body water
