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Frequency : Consistency is key

At 12 months, tirzepatide was associated with a greater mean weight loss of 14.7% compared to 10.8% for semaglutide

Key data point: in the retatrutide fatty-liver study, Sanyal and colleagues (Nature Medicine, 2024) reported liver fat falling 80 to 90 percent over 48 weeks in patients who started with fatty liver disease, a drop tied closely to the weight and belly-fat loss and, in theory, to glucagon-receptor-driven fat burning in the liver