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Mooney RA, Senn J, Cameron S, Inamdar N, Boivin LM, Shang Y, Furlanetto RW

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RM-718, PL7737 and 710GO all report efficacy with acceptable nonclinical safety profiles, including no evidence of cardiac activation (130)

Histopathological analysis of the hippocampus corroborates neurodegeneration in Parkinsons disease models, with untreated groups displaying markers such as gliosis, edema, and cortical neuron degeneration