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When the body cannot manage the toxic burden, oxidative stress results

Xu Z, Wu C, Sun-Waterhouse D, Zhao T, Waterhouse GIN, Zhao M

Oxidative stress results in excessive ROS production, which leads to the generation of polyunsaturated fatty acids that promote proteolysis, decreased secretion of low-density lipoprotein (LDL), and the accumulation of TGs in the liver ( Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular redox reactions